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br Experimental Procedures br Author
2019-08-13
Experimental Procedures Author Contributions Acknowledgments Introduction Oxysterols came to prominence in the late 1970\'s with the oxysterol hypothesis which proposed that the suppressive effect of cholesterol on its own synthesis is mediated through oxysterols not by cholesterol itsel
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Anti-cancer Compound Library Evidence for interactions betwe
2019-08-13
Evidence for interactions between the endothelin and the angiotensin system has also become plentiful. It has become clear that the two systems, in addition to acting independently, can act synergistically (Emori et al., 1989, Imai et al., 1992) as well as promote the peptide mRNA expression in endo
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In conclusion the present study demonstrates that E s antiap
2019-08-13
In conclusion, the present study demonstrates that E2\'s antiapoptotic effects are significantly reduced by coadministration of progestogens. The combination of E2 and progestogens resulted in diverging effects on the expressions of ERs and PRs, which induced different effects on the cell growth of
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Then the mechanisms responsible for
2019-08-13
Then the mechanisms responsible for BPA induced up regulation of ERRγ were further investigated. Recent studies indicated that Akt and MPAK can modulate the protein levels and transcriptional activities of ERRγ (Heckler et al., 2014, Sun et al., 2014). Previous studies also indicated that BPA can ac
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The presence of H PPases
2019-08-13
The presence of H+-PPases in parasitic protists raises the question of the physiological role of these proteins. So far, they had been extensively characterized mainly in higher plants, and some prokaryotes [1], [2], [3], [4], [5], [6], [7], [16], [20]. A common feature to all these organisms is tha
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It is of interest that an
2019-08-12
It is of interest that an initial maternal experience in virgin mice produces both changes in subsequent maternal behavior as well as possible changes in neural gene expression. Stolzenberg et al. (2012) proposed that experience-based changes in maternal responsiveness may be mediated by chromatin m
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Early VL diagnosis makes it possible to formulate a
2019-08-12
Early VL diagnosis makes it possible to formulate a quicker and more effective treatment against the disease, which could increase the possibility of a cure for the patients, as well as reduce the toxicity of the drugs (Coelho et al., 2009); however, conventional and molecular parasitological method
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Caspase-1, human recombinant proteinase A structural explana
2019-08-12
A structural explanation for how RBR RING1s handle their bound E2~Ubs differently from canonical RINGs has not been readily apparent. Only a few residue positions are strongly conserved in RING and RING1 domains, most of which are zinc-coordinating Cys and histidine residues. A key position in canon
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Colony stimulating factor receptor CSF R or
2019-08-12
Colony stimulating factor-1 receptor (CSF-1R or cFMS) is a type III receptor tyrosine kinase. It is activated by binding with CSF-1 and IL-34, which stimulates differentiation, proliferation, survival and migration of monocyte-macrophage lineage cells., , , Also, macrophages produce inflammatory me
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cholesterol absorption inhibitors Social interaction is know
2019-08-12
Social interaction is known to be the main source of stress in human beings (Dickerson and Kemeny, 2004, Tamashiro et al., 2005). An animal model of social stress should closely mimic real-life situations in human life (Neisewander et al., 2012); in this context, social defeat in an agonistic encoun
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br Outcome of COX overexpression Although a causal role
2019-08-12
Outcome of COX-2 overexpression Although a causal role for COX-2 has been proposed, mechanisms by which COX-2 function contributes to the pathogenesis of hyperplastic disease are not well defined. To examine if there is any correlation between COX-2 and p53 protein levels, Kumagai et al. [15] rec
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Role of ROS signaling in regulating cell death pathways
2019-08-12
Role of ROS signaling in regulating cell death pathways has been well established. Involvement of CLIC1 in ROS production has been studied earlier. It was observed that macrophages from clic1 mice showed ~30% decrease in cellular ROS generation which effects macrophage function (Jiang et al., 2012).
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The COMT gene is involved
2019-08-12
The COMT gene is involved in numerous psychological and physiologic processes, including modulation of pain. Polymorphisms in this gene have also been associated with many painful conditions, including pain sensitivity in children. Bivariate analysis demonstrated that individuals with heterozygous C
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As before all calculations are based on thermodynamically fi
2019-08-09
As before [3], [4], all calculations are based on thermodynamically first- and second-order hydropathic (amino acid) scales [6], [7], linearly scaled to a common center and a common range for each of the 20 amino acids. These are then converted to a triangular matrix , where is the length of a s
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P falciparum DHFR TS is a
2019-08-09
P. falciparum DHFR-TS is a particularly important enzyme, because it is from the protozoan species that is associated with most malaria infections. Since this enzyme is responsible for catalyzing sequential reactions in the thymidylate cycle, its inhibition slows malarial dTMP production and therefo
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