• In glucose stimulated pancreatic cells B

  2024-03-29

  

  In glucose-stimulated pancreatic β-cells, B-Raf activity is increased, while Raf-1 activity is under the detection limit (Duan and Cobb, 2010). Thus, B-Raf is the primary protein kinase involved in the rapid activation of ERK1/2 in glucose-treated pancreatic β-cells. Expression of a dominant-negativ

• Kidney contributes importantly to the long term blood pressu

  2024-03-29

  

  Kidney contributes importantly to the long-term blood pressure control via regulating sodium homeostasis. Renal proximal tubule (RPT) is one of the most critical segments for sodium reabsorption within kidney and therefore involved in blood pressure adjustment. This process is regulated by numerous

• br Introduction Chronic kidney disease CKD is a worldwide pu

  2024-03-29

  

  Introduction Chronic kidney disease (CKD) is a worldwide public health problem. This problem is even worse in socioeconomically deprived countries because lower income and social deprivation are associated with higher incidence of reduced GFR, progressive kidney function loss and end stage renal

• The Cebu Longitudinal Health and Nutrition Survey

  2024-03-29

  

  The Cebu Longitudinal Health and Nutrition Survey (CLHNS) genome-wide association study investigated the genetic loci associated with plasma adiponectin in 1776 unrelated Filipino women. Adiponectin was strongly associated with three genetic positions: the gene CDH13 (rs3865188, P ≤ 7.2 × 10−16), ne

• It involves complementary and inflammatory

  2024-03-28

  

  It involves complementary and inflammatory system proteins, mast cells, eosinophils, basophils, macrophages, natural killer (NK) cells and cytokines [1]. Innate immunity, not only include cells, but also barriers that defend the organism to the penetration of pathogenic agents [2]. Important mediat

• br Results br Discussion Context specific and

  2024-03-28

  

  Results Discussion Context-specific and dynamic post-translational protein modifications are well-established regulators of the signaling pathways that protect eukaryotic DNA integrity during the tremendous task of replication. Advancements in speed, resolution, and sensitivity of MS-based tec

• Non steroidal anti inflammatory drugs which include aspirin

  2024-03-28

  

  Non-steroidal anti-inflammatory drugs, which include aspirin and ibuprofen, target COX-2 activity to inhibit inflammation. It has been shown that daily use of a nonsteroidal anti-inflammatory drugs is associated with reduced ER-positive breast cancer recurrence in obese and overweight women. More pr

• br Discussion Arginase and Arginase are

  2024-03-28

  

  Discussion Arginase 1 and Arginase 2 are homologous enzymes that consume l-arginine to produce l-ornithine and urea [14], [15]. These enzymes compete with NO synthases for the same substrate [14], [15], [30], and therefore may reduce NO production [21], [24], [30]. The colocalization of arginase

• br Results br Discussion AP a heterodimeric

  2024-03-28

  

  Results Discussion AP-1, a heterodimeric transcription factor comprising various combinations of FOS, JUN, MAF, ATF, and CREB family proteins, has been known to play a pivotal role in leukocyte development for decades (Liebermann et al., 1998; Valledor et al., 1998). However, its participation

• br Materials and Methods br Results br Discussion

  2024-03-28

  

  Materials and Methods Results Discussion XHP is a traditional Chinese anti-cancer medicine that is widely used for the treatment and adjuvant treatment of breast cancer. XHP has been shown to induce apoptosis in various breast cancer Azaperone mg in vitro, including Hs578T, MCF-7, and MDA-

• Reactive oxygen species is an aspect

  2024-03-28

  

  Reactive oxygen species is an aspect of oxidative stress which are associated with many diseases such as rheumatoid arthritis, diabetes, inflammation, atherosclerosis and cancers (Collins, 2005; Halliwell, 1994). Thus, the need for naturally occurring antioxidants is of crucial importance. Some biop

• Introduction Heterotrimeric G proteins mediate signal transd

  2024-03-28

  

  Introduction Heterotrimeric Gαβγ proteins mediate signal transduction through seven-transmembrane domain receptors. In response to neurotransmitters or hormones, activated receptors bind GTP via the Gα subunit leading to the dissociation of Gα from the Gβγ dimer. G proteins regulate the levels of s

• An in vitro assay in which endothelial cells

  2024-03-28

  

  An in vitro assay in which endothelial cells form 3D tube-like structures was used to investigate effects of dNK on vessel stability. The results indicate that dNK cells from women with high spiral artery resistance index had reduced ability to activate endothelial cells, since endothelial cells pre

• One of the specifications of the NIA AA research

  2024-03-27

  

  One of the specifications of the NIA-AA research framework was that it prostaglandin synthase be applicable in two distinct research contexts—interventional trials and observational research. In many if not most modern AD interventional trials, individuals are selected for inclusion with the aid of

• In this study using pure enzyme preparations of human

  2024-03-27

  

  In this study, using pure enzyme preparations of human placental recombinant AR (hAR) and of AR isolated from bovine lens (bAR), which behave as Michaelis eletriptan hydrobromide with glyceraldehyde as substrate, is shown that an apparent negative cooperativity action for glucose still occurs. We pr

15504 records 186/1034 page Previous Next First page 上5页 186187188189190 下5页 Last page