• Taniyama et al reported a female with infertility who had

  2024-02-23

  

  Taniyama et al. reported a female with infertility who had a homozygous T-to-A transversion at nucleotide position g.2472 in exon 3 of the CYP17A1 gene (mutation Y201N) and decreased 17-hydroxylase and 17,20-lyase activities of TUG 891 was initiated using dexamethasone to control adrenal P producti

• Production of reactive oxygen species

  2024-02-23

  

  Production of reactive oxygen species (ROS) during RSV infection is one the important ways that neutrophils can injure the lungs [2], [24], [25]. Lipoxygenases are considered as an important source of producing ROS inside the KP372-1 [26]. Several studies have indicated that the 12/15-LOX is a pro-

• SB 216763 br The role of LOX plays in autophagy Autophagy is

  2024-02-23

  

  The role of 12/15-LOX plays in autophagy Autophagy is a process by which cellular material is delivered to lysosomal to degrade the damaged organelles and proteins to facilitate nutrient recycling (Towers and Thorburn, 2016). There has been characterized three types of autophagy-macroautophagy, m

• We also showed that steatosis

  2024-02-23

  

  We also showed that steatosis induced an additional increase of ASK1 activation that was associated to the exacerbation of hepatocyte and liver damage and was unrelated to ER stress. Indeed, several settings, also different to ER stress, can induce ASK1 activation and many of them involve oxidative

• Another heroic set of studies combining retrodialysis

  2024-02-23

  

  Another heroic set of studies combining retrodialysis with electrophysiological recording at two distinct brain sites further indicated that the estradiol-induced increase in auditory-evoked firing in NCM also enhanced the selectivity of auditory-evoked responses in the downstream sensorimotor nucle

• DMPO Aerobic exercise plays an important role in the regulat

  2024-02-22

  

  Aerobic exercise plays an important role in the regulation of DMPO metabolism in the skeletal muscle. It is also associated with increases in AMPK and GLUT4 levels, resulting in the improvement of the glucose uptake signaling pathway [17,18]. Recently, it has been shown that exercise markedly incre

• br Results br Discussion Here we uncovered a

  2024-02-22

  

  Results Discussion Here, we uncovered a role for Wnt-Fz7 signaling in LTP-dependent spine plasticity and synaptic localization of AMPARs. We demonstrated that LTP induction increased Wnt7a/b protein at Nitrendipine and spines. Direct blockade of endogenous Wnts impaired LTP-mediated structura

• In this report we introduce

  2024-02-22

  

  In this report, we introduce a new method for identifying aminopeptidases. Because single substrates can be insufficient for enzyme identification, we used an entire library of substrates to obtain more information about enzyme activity and to directly detect aminopeptidases. Moreover, substrates ca

• br Acknowledgements br Introduction Microbial enzymes

  2024-02-22

  

  Acknowledgements Introduction Microbial enzymes have gained interest for their widespread uses in industries and medicine owing to their stability, catalytic activity, and ease of production and optimization than plant and animal enzymes (Singh et al., 2016). Microbial aminopeptidases (amino-a

• SU5416 Recently two distinct small molecule inhibitors of PH

  2024-02-22

  

  Recently, two distinct small-molecule inhibitors of PHGDH were identified using high-throughput screens, both of which inhibit de novo serine biosynthesis and show selective toxicity to cancer SU5416 with high SSP flux [50,51]. The inhibitor NCT-503, which has an IC50 of 2.5μM, reduces the growth a

• The diversity of metabolic adaptations employed

  2024-02-22

  

  The diversity of metabolic adaptations employed by cancer cells in response to rapidly changing conditions, contributes to their biological aggressiveness and therapeutic resistance by enabling them to proliferate when nutrients are plentiful and to shift their resources to survival when nutrients a

• Since the publication of the guidelines

  2024-02-22

  

  Since the publication of the 2011 guidelines, data have continued to accumulate indicating that the cognitive decline in AD occurs continuously over a long period [6–8], and that progression of biomarker measures is also a continuous process that begins before symptoms [9–14]. Thus, the disease is n

• Various compounds have been designed to inhibit

  2024-02-22

  

  Various compounds have been designed to inhibit aldose reductase (AR) [12]. These compounds can be classified into two main categories, the first category comprises those containing a carboxylic Quetiapine moiety, for example, 3-thiazolidineacetic acid derivative, which has been reported to be a po

• Through systematic deletion of AhR

  2024-02-22

  

  Through systematic NNC 55-0396 of AhR in specific cell types, Di Meglio et al. (2014) revealed that AhR in keratinocytes and fibroblasts are key to the exacerbated psoriatic phenotype induced by IMQ in AhR-deficient mice. This emphasizes the crosstalk between keratinocytes and the immune system to

• Taken together the results reveal a complex feedback and

  2024-02-22

  

  Taken together, the results reveal a complex feedback and feedforward signaling network between the tryptophan metabolic enzymes IDO1/TDO2, the KP metabolite KYN, and the ligand-activated transcription factor AhR (Figure 2). Cancer p97 highjack this signaling circuitry to deregulate immunological r

15376 records 196/1026 page Previous Next First page 上5页 196197198199200 下5页 Last page