• br Materials and methods br Results br Discussion In

  2024-12-17

  

  Materials and methods Results Discussion In the present study, we aimed to elucidate the contribution of adenosine receptors to vascular tone in mice with T1D. We showed that diabetes resulted in decreased A1 adenosine receptor-mediated contraction in the aorta, which was accompanied by inc

• br Introduction Epilepsy is characterized by spontaneous rec

  2024-12-17

  

  Introduction Epilepsy is characterized by spontaneous recurrent seizures and represents one of the most frequent neurological diseases affecting about 60 million people worldwide (McNamara, 1999). It is estimated that up to 50% of all cases are triggered by “initial precipitating injuries”, such

• Caspase Inhibitor Set I Among different classes of pesticide

  2024-12-17

  

  Among different Caspase Inhibitor Set I of pesticide, organophosphates as well as pyrethroids are more frequently used because of their high insecticidal property, low mammalian toxicity, less persistence and rapid biodegradability in the environment. These compounds are used extensively in agricul

• Furthermore our lab previously reported that

  2024-12-17

  

  Furthermore, our lab previously reported that cadmium treatment increased AChE-S and decreased AChE-R variants gene expression, which mediates the cell death observed on basal forebrain cholinergic neurons (Del Pino et al., 2016b). AChE-R decreased expression, which presents a neuroprotective role i

• The adult muscle type acetylcholine receptor AChR the

  2024-12-17

  

  The adult muscle-type N1-Methylpseudo-UTP receptor (AChR), the exemplar pLGIC, is a heteropentamer comprising two α subunits, and one each of the β, δ, and ɛ subunits (Sine, 2012). These five subunits come together in a counterclockwise α-ɛ-α-δ-β arrangement (Figure 1A). Binding of acetylcholine to

• In the final set of experiments the dependence of

  2024-12-17

  

  In the final set of experiments, the dependence of the reaction rate on viscosity was determined. The experimental protocol previously used to study the reaction of LOX with AA was used., Reactions of 5-LOX and AA were carried out at different relative viscosities in Tris buffer (25mM, pH 8.0) at 2

• 23401 zip code However although in vitro studies in heterolo

  2024-12-17

  

  However, although in vitro studies in heterologous systems have provided very important indications of potential novel pharmacology, the studies with endogenous receptors in native tissues are essential to provide evidence for GPCR heteromerization in vivo and to confirm its physiological relevance.

• MafB a member of the

  2024-12-17

  

  MafB, a member of the Maf protein family, is essential for terminal differentiation of macrophages (Kelly et al., 2000). The phagocytic activity of polystyrene beads was found to be enhanced in Telatinib with exogenous expression of MafB (Tillmanns et al., 2007). However, in alveolar macrophages of

• Based on these findings the time point for manipulating

  2024-12-17

  

  Based on these findings, the time point for manipulating autophagy may also determine its role, whereby autophagy induction performed before ischemia could play a protective role but have an opposite effect once ischemia/reperfusion has occurred. This hypothesis is further supported by the protectiv

• br Materials and methods br

  2024-12-16

  

  Materials and methods Results Discussion Many studies investigate the role of 12/15-LOX in cancer cell,23, 24, 25 however we here first found that host 12/15-LOX also plays an important role in metastasis progression. We have demonstrated that 12(S)-HETE increased melanoma cell adhesion to

• bcrp transporter Herbal medicines have been used to treat va

  2024-12-16

  

  Herbal medicines have been used to treat various types of diseases and disorders for thousands of years worldwide (Li and Brown, 2009). Natural products have been the remedy of cancer chemotherapy for the past several decades. Anisomeles indica (L.) Kuntze. (Labiatae), commonly known as 'yu-chen-tsa

• Another contributor for the G

  2024-12-16

  

  Another contributor for the G2/M arrest in A549 and H1299 cells might be p21WAF1/CIP1 which was up-regulated upon ovatodiolide treatment. p21WAF1/CIP1 is a common CDKs inhibitor which blocks Fmoc-Leu-OH G2/M phase progression in various types of cancer cells (Kim et al., 2015, Liberio et al., 2015)

• br Antioxidant polymers conjugates Natural antioxidants are

  2024-12-16

  

  Antioxidant-polymers conjugates Natural antioxidants are usually used as a substitute for synthetics but some degradation phenomena could influence their applications. For example, ascorbic interleukin 1 receptor antagonist as a natural antioxidant undergoes yellowish coloration as a result of o

• Although AMPK is a negative regulator of bioenergetic reprog

  2024-12-16

  

  Although AMPK is a negative regulator of bioenergetic reprogramming in cancer cells, little is known about the role of AMPK in immunometabolism in sepsis. Our current study indicates that AMPKα dysfunction enhances PKM2-dependent aerobic glycolysis, which results in HMGB1 release in macrophages and

• br Material and methods br Results br Discussion

  2024-12-16

  

  Material and methods Results Discussion RSV is a major cause of lower respiratory tract infections in infancy and early childhood. Several observations suggest that immunological mechanisms may be the key to understand the severity of RSV bronchiolitis in infancy. Several laboratories have

15508 records 51/1034 page Previous Next First page 上5页 5152535455 下5页 Last page