• br Introduction Stroke is the second cause of

  2022-02-23

  

  Introduction Stroke is the second cause of death worldwide and the first cause of acquired motor disability in adults [1], [2]. In sub-Saharan Africa, stroke is the first cause of admission in neurology departments [3]. In Cameroon, the in-hospital mortality of stroke is estimated at 26.8% [4]. A

• Drosophila is a well established model to investigate the mo

  2022-02-23

  

  Drosophila is a well-established model to investigate the molecular and cellular defects underlying human neurodevelopmental disorders (Oortveld et al., 2013, van der Voet et al., 2014). Here, we establish Drosophila as a model for understanding the mechanisms linking mutations in KDM5 family protei

• Lactate LA the end product of aerobic glycolysis has been

  2022-02-22

  

  Lactate (LA), the end product of aerobic glycolysis, has been long neglected and seen as a byproduct until recently the findings for its important role in global gene transcription, cancer progression, functional polarisation of immune chloride channels and the sustenance of stem cells [[7], [8], [9

• Similar to GPR A activation of

  2022-02-22

  

  Similar to GPR109A, activation of G-protein-coupled receptor 81 (GPR81, also called HCAR1 (hydroxycarboxylic PF2341066 receptor 1)) by lactate suppresses lipolysis (Fig. 1), suggesting GPR81 to be a potential drug target for treating T2DM (Boyd et al., 1974, Cai et al., 2008, Gold et al., 1963, Hou

• Considering that loss of LAG

  2022-02-22

  

  Considering that loss of LAG-3 3MB-PP1 results in increased CD4+ T cell homeostatic expansion, and that the ability of a cell to proliferate is tightly coupled to its metabolic profile, we hypothesized that LAG-3 regulates naive CD4+ T cell metabolism. Our results indicate that, indeed, Lag3-defici

• 51 8 Interestingly mGlu and mGlu receptors differ notably by

  2022-02-22

  

  Interestingly, mGlu2 and mGlu3 receptors differ notably by their cellular distribution. Whereas mGlu2 receptors are mostly neuronal, mGlu3 receptors are expressed both in glia and in neurons. In neurons, mGlu3 receptors are present at the post-synapse and in presynaptic elements (Tamaru et al., 2001

• To maintain low Glu concentrations

  2022-02-22

  

  To maintain low Glu concentrations in the synaptic cleft below the affinity of its receptors, this amino AC220 ic50 is rapidly removed from the extracellular space by a family of sodium-dependent high-affinity transport systems located mainly in the plasma membrane of perisynaptic astrocytes, and i

• br Acknowledgments This research was

  2022-02-22

  

  Acknowledgments This research was supported by a grant from the Korea Health Technology R&D Project through the Korean Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (grant number: HI17C0616). Dr. Jun-Mo Yang was supported by the Natio

• A main finding of this study was that the

  2022-02-22

  

  A main finding of this study was that the impact of exogenous insulin on hippocampal memory and glucose utilization was GluT4-dependent. Although insulin was administered directly to the hippocampus, it is important to point out that such administration does indeed have physiological relevance; that

• Introduction Glucocorticoids are released in

  2022-02-22

  

  Introduction Glucocorticoids are released in response to stress and play an important role in inflammation, cellular growth, development, body fluid homeostasis, carbohydrate, lipid, and protein metabolism. However, circulating glucocorticoid excess has been associated with a classical phenotype of

• br Introduction Glucagon is a peptide hormone that acts

  2022-02-22

  

  Introduction Glucagon is a peptide hormone that acts to increase blood glucose levels. The secretion of glucagon from the alpha NVPBEZ235 of the islets of Langerhans in the pancreas is increased during fasting and prevents hypoglycemia. Glucagon increases glycogenolysis and gluconeogenesis and th

• Medulloblastoma predominantly occurs in infants and children

  2022-02-22

  

  Medulloblastoma predominantly occurs in infants and children, and is the most-common type of paediatric malignant GW311616 hydrochloride tumour, accounting for about 20% of all childhood brain tumors [63]. According to cancer genomics, medulloblastoma consists of at least 4 distinct subgroups: Hh dr

• Cx is a phosphoprotein that is predominantly

  2022-02-22

  

  Cx43 is a phosphoprotein that is predominantly phosphorylated in the control state. Cx43 can be phosphorylated by a number of kinases and dephosphorylated by protein phosphatases such as PP1 and PP2A [6], [10]. Posttranslational phosphorylation of Cx43 is thought to influence intercellular coupling

• The structural similarity software vROCS OpenEye has

  2022-02-22

  

  The structural similarity software vROCS (OpenEye) [45] has been utilized by Musumeci et al. [46] to screen the Maybridge [47] HitFinder database (∼14,400 compounds) using Distamycin A (Fig. 3B) as a query. Using the Tanimoto coefficient (Section 6.4) and vROCS's colour scoring (atom/feature similar

• FFAs are essential nutritional molecules that can

  2022-02-21

  

  FFAs are essential nutritional molecules that can also modulate numerous cellular functions. Fatty Dexlansoprazole derivatives like prostaglandins, leukotrienes lysophosphatidic acid, spinhgosine-1-phosphate and others are well documented to carry out signal transduction via G-protein coupled recep

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