• A growing number of other post translational modifications a

  2021-08-06

  

  A growing number of other post-translational modifications are implicated in regulation of the ubiquitin system, including substrate modification by hydroxylation, glycosylation, acetylation, methylation, modification by poly(ADP-ribose) (PAR), and attachment of ubiquitin-like modifiers. The HIF1-α

• These studies established IAP proteins as dimeric RING E lig

  2021-08-06

  

  These studies established IAP proteins as dimeric RING E3 ligases, but did not account for the essential role of dimerization. In IAPs and related E3s, such as RNF4 and MDM2, dimerization not only depends on contacts from the core RING domain but also residues N- and C-terminal to the RING domain (B

• br E mediated E discharge E ligases simultaneously

  2021-08-06

  

  E3-mediated E2 discharge E3 ligases simultaneously interact with the substrate and the SUMOD charged E2 enzyme to catalyze the discharge of the thioester-bound SUMOD from the E2 to the substrate. E3 interaction with SUMOD via a SIM results in a closed conformation which is highly reactive and lea

• SIRT is a representative member of Sirtuins

  2021-08-06

  

  SIRT1 is a representative member of Sirtuins, which is a family of highly conserved NAD+-dependent class III histone deacetylases. SIRT1 deacetylates plentiful nonhistone protein substrates [Atgs, Foxo1, Foxo3, PGC-1α, NF-kB, E2F1 and p53] (Conrad et al., 2016; Gu et al., 2016; Tu et al., 2018) to p

• Recent results from our group found that SPMs not

  2021-08-06

  

  Recent results from our group found that SPMs, not only play a part in terminating inflammation, but also have a physiological role in conjunctival goblet calculate the molarity of a solution to maintain ocular surface health in the absence of disease. Amongst the SPMs that are effective in the con

• It is of interest to consider an

  2021-08-06

  

  It is of interest to consider an explanation for the apparent phosphorylation of hSSB1 in undamaged cells. One such may be that in order to execute a rapid response to replication inhibition, basal S134 phosphorylation could function to keep hSSB1 in a ‘primed’ state prior to stress. Such an arrange

• Previous studies have indicated that

  2021-08-06

  

  Previous studies have indicated that hSSB1 may be phosphorylated at threonine residue 117 (T117) [13] and acetylated at lysine residue 94 (K94) [15], both of which promote hSSB1 function in response to ionising radiation exposure. Mass spectrometry screens of proteins immunoprecipitated with phospho

• br Material and methods br

  2021-08-06

  

  Material and methods Results and discussion Conclusions Acknowledgements S. De thanks DST, New Delhi for generous grant of the SERC Fast Track Scheme No. SR/FT/CS-057/2008. R. Kundu thanks the University of Kalyani for financial assistance. We are grateful to Prof. K. Bhattacharyya of IA

• The primary aim of this study was

  2021-08-06

  

  The primary aim of this study was to evaluate DAPK methylation as a tumor marker which is not only detected in the primary tumor but also in the serum of patients. We used matched pre-operative serum samples to determine the correlation of tumor and serum results. Despite an equal methylation freque

• br Author contributions br Conflicts

  2021-08-06

  

  Author contributions Conflicts of interest Introduction Current the 5-year survival rates for lung and pancreatic cancers are 18% and 8%, respectively. These low survival rates are partially because of the late diagnosis of one-half of cases, in which 5-year survival decrease to 4% and 3%,

• Currently approved anti obesity drugs for

  2021-08-06

  

  Currently approved anti-obesity drugs for long term use such as orlistat, lorcaserin and liraglutide are efficient in reduction of weight gain but are limited in usage due to their adverse effect profile and higher cost (Krentz et al., 2016; Mopuri and Islam, 2017). In 59 7 mg to this, plant derived

• br Discussion Personality develops throughout a human s life

  2021-08-05

  

  Discussion Personality develops throughout a human's life and is related to his or her innate temperament. While personality features are shaped by various experiences of daily life and moderate a wide range of specific behaviours related to particular situational contexts, temperament reveals it

• In rodent models the loss of estrogens through ovariectomy h

  2021-08-05

  

  In rodent models, the loss of estrogens through ovariectomy has been shown to promote the development of intracranial aneurysms. Conversely, the administration of an straight from the source receptor beta agonist restores its protective effect, but is abolished with the introduction of a nitric oxi

• br Membrane receptor Indirect non

  2021-08-05

  

  Membrane receptor: Indirect non-genomic signaling As mentioned above, not all SC-514 responses fit the classical genomic model of steroid action. The observation of excessively fast estrogen-induced biological responses led to the development of the hypothesis that estrogen could be acting by me

• Given the potency enhancing effect of the butyl group

  2021-08-05

  

  Given the potency enhancing effect of the 4--butyl group, this substitution was incorporated into the Eastern portion of the molecule for further SAR investigations (). Removal of the phenol group (SR19822) or moving it from the -position to the -position (SR19552) or led to significant loss of acti

15493 records 640/1033 page Previous Next First page 上5页 636637638639640 下5页 Last page