• In cancer interactions between the

  2020-12-31

  

  In cancer, interactions between the transformed cancer ON-01910 and other cell types recruited to the tumor are important. Tumor associated macrophages provide cancer cells with a suitable low-grade inflammatory milieu including growth promoting factors. Our results suggest a novel pro-tumorigenic

• Another well established visceral action of CRF

  2020-12-31

  

  Another well-established visceral action of CRF and urocortin administered peripherally is the long-lasting lowering of blood pressure observed in various species ranging from rodents to humans [22]. Existing evidence suggests that the hypotensive action of CRF and urocortin is mediated by the inter

• One common method to replace

  2020-12-31

  

  One common method to replace the wet limestone process is the use of an amine-based solution as an absorbent to capture SO2. However, almost all of the common amine-based absorbents are highly volatile compounds, whose emissions are air pollutants themselves. Therefore, it is desirable to either use

• Citrus comprising some of the most widely

  2020-12-31

  

  Citrus [29], comprising some of the most widely cultivated fruit crops worldwide, has been consumed as a food and dietary supplement. According to traditional Chinese medicine, dry pericarp of Citrus, as a Chinese herbal remedy, is capable of regulating Qi and expelling phlegm, and has been used to

• The interest for lanthanide and actinide

  2020-12-31

  

  The interest for lanthanide and actinide complexes appeared again recently, due to their unique features in the design of Single Molecule Magnets (SMM). Lanthanide SMMs are interesting due to large their intrinsic magnetic anisotropy, but their core 4f orbitals minimally participate in exchange inte

• br Methods br Results br

  2020-12-31

  

  Methods Results Discussion Literature showed SN was well studied for its antigastric ulcer, antiinflammatory, antihyperglycemic, and antihyperlipidemic properties. Although a recent publication reported that SN was found to exert its regulatory effect in animal cholesterol levels, the exac

• Finally naringin and hesperidin have different

  2020-12-31

  

  Finally, naringin and hesperidin have different glycosidic moieties (neohesperidose α-1,2 and rutinose α-1,6 respectively), bound in the same C7 position on the A ring of the flavonoid. The higher value of k/KM of RHA-Phis towards the former substrate suggests that the enzyme shows a preferential hy

• Even minor alterations in the surfactants structure could

  2020-12-31

  

  Even minor alterations in the surfactants structure could have consequences on their physico-chemical characteristics; mono-RLs have less solubility, stronger surfaces sorb, and stronger cationic metals binding than homologue di-RLs (Zhang et al., 1997). The HPLC separation of RLs structure is base

• There are five phosphorylated serines

  2020-12-30

  

  There are five phosphorylated serines in β-casein. However, only phosphorylated Ser35 was identified in the samples hydrolysed with GE at 37 and 50 °C, i.e., f32-42 and f32-44 of β-casein. The identification indicates that phosphorylated peptides were less detectable from the non-phosphorylated pept

• In our study the TIP P model is applied

  2020-12-30

  

  In our study, the TIP3P model is applied for water, AMBER99sb force field [24] is used to describe three types of EGFR, including the wild type (PDB: 2ITY) [25], its mutant G719S (PDB: 2ITO) [25] and mutant T790M (PDB: 3IKA) [26]. The force field of Tubemoside molecule is parameterized with optimize

• Like all other cellular processes ubiquitination is also

  2020-12-30

  

  Like all other cellular processes, ubiquitination is also tightly regulated; more so, as myriads of pathways are controlled via this conjugation and dysregulation of ubiquitination has been implicated in various diseases including cancer [16], [17]. Quite a few of such regulatory mechanisms that con

• To examine the influence of aromatic motifs

  2020-12-30

  

  To examine the influence of aromatic motifs on the bridging lysine esters we analysed DNA alkylating activity of the set of compounds 1–6. The lysine derivatives were chosen as it is relatively easy to prepare different esters and thereby study the impact of different groups on the reactivity toward

• W123 br Experimental section br Author contributions br Ackn

  2020-12-30

  

  Experimental section Author contributions Acknowledgements Introduction Many W123 in cells are sequential enzymatic reactions where the product of one enzyme serves as the substrate of a second enzyme (1, 2). Experimental evidence suggests that some of these consecutive enzyme-catalyzed

• Interestingly genome wide association studies

  2020-12-30

  

  Interestingly, genome-wide association studies have linked the chromosomal region harboring RDHE2 (SDR16C5) and seven other genes to stature and growth in cattle, humans, and pigs [30], [31], [32], [33], [34], [35], [36], [37], and beak deformity in chickens [38]. The most recent study specifically

• br Experimental procedures br Introduction Protein kinases r

  2020-12-30

  

  Experimental procedures Introduction Protein kinases represent one of the largest enzyme ML-098 in the human genome and act as signaling mediators in a variety of cellular processes (Manning et al., 2002). Because many diseases are associated with aberrant protein kinase activity, targeted kin

14960 records 731/998 page Previous Next First page 上5页 731732733734735 下5页 Last page