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In the course of this study
2019-09-24
In the course of this study, K+PFOS did not appear to have any effect on the thyroid parameters evaluated (H&E histology, follicular epithelial cell proliferation, and follicular epithelial apoptosis). This is an interesting observation considering the fact that treatment with K+PFOS resulted in act
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br Conflict of interest br Acknowledgments and
2019-09-24
Conflict of interest Acknowledgments and funding We thank Jaakko Matomäki, MSc, for the statistical analysis of the data. The study was supported by the Medical Research Council of the Academy of Finland, Decisions no. 250124 and 250114 (Centre of Excellence in Molecular Systems Immunology and
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Since both the Ub and ISG systems are
2019-09-24
Since both the Ub and ISG15 systems are crucial for the innate immune response, many prokaryotic and viral pathogens have evolved ways to hijack them in order to create a “window-of-opportunity” for efficient replication. Several viral and bacterial proteins have been found to directly target these
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MDV3100 and br Introduction In addition to the
2019-09-24
Introduction In addition to the canonical double stranded structure, DNA can form various higher order structures such as bulges, and various kinds of mismatches, triplexes, to the G-quadruplex (G4). Over the past decades, accumulating evidence has begun to emerge that these non-canonical structu
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In this study we examined a possible association
2019-09-24
In this study, we examined a possible association between the 19-bp N-3-oxo-dodecanoyl-L-Homoserine lactone and and the 9-bp repeat in the DHFR gene and the risk of spina bifida in 121 mothers of a spina bifida affected child, 292 control women, 109 spina bifida patients and 234 pediatric controls u
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Multiple sequence alignment of the proteins
2019-09-24
Multiple sequence alignment of the proteins in the DGAT1 sub-family shows that there are about 41 conserved amino Anhydrotetracycline hydrochloride pathway residues distributed over seven sequence motifs [74]. Unlike DGAT2, a large number of DGAT1 residues, including a majority of the conserved res
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In vitro work by us and others revealed that
2019-09-24
In vitro work by us and others revealed that high affinity interaction with collagen requires dimerization and/or pre-oligomerization of DDR1 (Agarwal et al., 2007, Abdulhussein et al., 2008, Leitinger, 2003). It has also been reported that a significant percentage of the DDR1 population forms ligan
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The notion that a small
2019-09-23
The notion that a small subset of inducible cellular transcripts, encoding immunological important factors, is translocated across the nuclear envelope by the karyopherin CRM1 is gaining support from various recent studies. For example, experimental evidence has been provided demonstrating that the
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In a cell based functional assay the
2019-09-23
In a cell-based functional assay, the antagonist properties of were assessed by measuring inhibition of CRF-stimulated cyclic adenosine monophosphate (cAMP) production in human Y-79 retinoblastoma cells. produced a concentration-dependent inhibition of CRF (1nM)-induced cAMP production with an IC
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Introduction It has been well stablished the role of
2019-09-23
Introduction It has been well stablished the role of CRF in somatic pain regulation (Yarushkina et al., 2011, Yarushkina et al., 2016). However, the effects of CRF in pain relief are controversial and it has been described anti- and pronociceptive effects (Ji et al., 1995, Larauche et al., 2009, Ni
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Methylated CpGs can recruit transcriptional co repressors to
2019-09-23
Methylated CpGs can recruit transcriptional co-repressors to prevent transcription factors (TFs) from promoting gene expression by tightly packing gap 27 structures [38]. Two CpG islands in the IPT5b promoter region showed higher methylation level in M9 rootstock compared to Mr (Fig. 3b). However,
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Previous work examining the link between
2019-09-23
Previous work examining the link between the COMT gene and ISV is limited and has produced contradicting results. The Val allele was linked with higher ISV of RTs following target trials in a continuous performance task (Stefanis et al., 2005) and with higher ISV of RT and P3b latencies of unfamilia
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We hypothesize that both IGF dependent kinase activation
2019-09-23
We hypothesize that both IGF-1-dependent kinase activation and locally synthesized neuroestrogens interactively regulate estrogen receptor activity in neuronal bgj mass in the absence of exogenously applied estradiol. The Neuro-2A cell line was chosen as the model system for these studies because I
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Estrogens Definition and history The term estrogens
2019-09-23
Estrogens: Definition and history The term “estrogens” refers to a group of female hormones, including estrone, estradiol, estriol, and estretrol (Fig. 1). Chemically, estrogens belong to the family of organic compounds known as steroids. As such, their core structure is composed of 17 carbon-carbo
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It is very important to decide
2019-09-23
It is very important to decide what the best time of NIR laser irradiation is for the optimized PTT. So the best way is to monitor the biodistribution of the nanoparticles in various tissues (specially, in tumors) temporally and spatially after iv injection. Based on the combined functions of therap
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